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Percocet 10 mg no prescription needed. Known as a painkiller, Percocet 10 mg is sometimes provided for patients who have undergone surgical procedure., Percocet 10 mg no prescription needed Known as a painkiller, Best online Percocet Prices

Generic Name: Oxycodone, Acetaminophen
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Percocet can be called a perfect solution for people suffering from acute pain. This medicine also contains aspirin which is again a pain reliever. Apart from acting as a pain reliever, it also cures inflammation and fever. Apart from aspirin, Percocet also contains Oxycodone and this combination can be very helpful in treating moderate pain to severe pain. Doctors can prescribe Percocet to the patients who have recently undergone severe surgery or are suffering from severe painful conditions. Such patients can buy Percocet with prescription. Buying this medicine without prescription can affect a person’s health and can also create legal implications. Apart from treating pain, inflammation or fever, this drug can also be used under other medical conditions.

This is a medication that has been endorsed by the FDA in order to help patients who are undergoing intense pain. While you can buy this drug from nearby drugstores, it is possible to avail of next-day shipment of Percocet from online pharmacy. But before you obtain the positive factors of the medications that are offered in online pharmacies, you have to be aware of some precautionary measures. This kind of information may be obtained through research, your specialist, or from online medical sites.     Before you decide to order and avail of next-day shipment of Percocet 10mg from online pharmacy, it is essential to educate yourself regarding this drug and its effects on your body, especially your central nervous system. The typical side effects of Percocet, which you might feel after taking the drug, include feeling nauseated, lightheaded, and dizzy. What you need to avoid from is mounting forbearance over the drug, especially if you have been taking it for some time. This is the reason why you need to consult with your doctor about the likely side effects of Percocet 5 mg. On the other hand, you can also know more about the different reactions of the body to the medicine by talking to a pharmacist. Aside from being able to obtain Percocet overnight delivery from online pharmacy, it is possible to order it without needing a prescription. Online pharmacies abroad offer OTC Percocet, which is not provided within U.S. online pharmacies. When you want to be assured of the drug’s quality, you have to opt for prescribed Percocet overnight delivery from online pharmacy. The doctor’s recommendation for the medicine is faxed over to the online pharmacy, from where you will be buying Percocet 5mg. With the rules of the FDA controlling the operation of the pharmacy, you are provided with assurance. Some of these are discounted prices, convenient method of buying medicines, and guaranteed high-quality drugs.Buy Percocet 30mg cheap Drugs contain a lot of chemicals and it is a well known fact that chemicals have their own side effects. Before buying any drug, you should know the side effects and ways to avoid them. The online pharmacies have made it possible for anyone to buy any drug of their choice without worrying about getting a prescription from a doctor. This has made is possible to buy Percocet 30 mg online and hence, you should be cautious with the way you use the drug.

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Percocet Generic Name: OXYCODONE (ox-i-KOE-done) and ACETAMINOPHEN (a-seat-a-MIN-oh-fen)

Percocet Drug Manufacturer: ENDO PHARMACEUTICALS

Percocet Common Uses: This medicine is a combination of a narcotic and acetaminophen used to relieve moderate to severe pain. Narcotic pain-relievers work by binding to opioid receptors in the brain and spinal cord, and acetaminophen decreases the formation of prostaglandins, therefore reducing pain. This medicine may also be used to treat other conditions as determined by your doctor.

How to use this Percocet Medicine: Follow the directions for using this medicine provided by your doctor. Take this medicine by mouth. THIS MEDICINE MAY BE TAKEN WITH FOOD if it upsets your stomach, although doing so may decrease its effectiveness. Consult your doctor or pharmacist about alternatives for decreasing nausea (e.g., antihistamines, lying down for 1-2 hours with minimal head movement). STORE THIS MEDICINE at room temperature between 59 and 86 degrees F (15 and 30 degrees C) in a tightly-closed container, away from heat, moisture, and light. IF YOU MISS A DOSE OF THIS MEDICINE and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Percocet Cautions: DO NOT TAKE THIS MEDICINE IF YOU HAVE HAD A SEVERE ALLERGIC REACTION to codeine, hydrocodone, dihydrocodeine, or oxycodone (such as Tylox, Tylenol with Codeine, Vicodin). A severe allergic reaction includes a severe rash, hives, breathing difficulties, or dizziness. If you have a question about whether you are allergic to this medicine or if a certain medicine contains codeine, hydrocodone, dihydrocodeine, or oxycodone, contact your doctor or pharmacist. Monitor your pain as directed by your doctor. If pain is left untreated and becomes intense, this medicine may not work as well to relieve it. DO NOT EXCEED THE RECOMMENDED DOSE, take this medicine more often, or for longer than prescribed without checking with your doctor. Exceeding the recommended dose or taking this medicine for longer than prescribed may be habit-forming. If using this medicine for an extended period of time, DO NOT SUDDENLY STOP taking this medicine without your doctor’s approval. When using for an extended period, this medicine may not work as well and may require different dosing. Talk with your doctor if this medicine stops working well. THIS MEDICINE MAY CAUSE drowsiness or dizziness. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. AVOID ALCOHOLIC BEVERAGES while taking this medicine. To minimize dizziness or lightheadedness, get up slowly when rising from a seated or lying position. To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. If you become constipated while using this medicine talk with your doctor or pharmacist. This medicine contains acetaminophen. Adults should not take more than a total of 4 grams of acetaminophen per day (3 grams per day if you have liver disease). Consult your doctor or pharmacist for more information. Acetaminophen may cause liver damage. If you drink alcohol on a daily basis, do not take this medicine without first discussing it with your doctor. Alcohol use combined with acetaminophen may increase your risk for liver damage (symptoms include yellowing eyes or skin, stomach pain, dark urine). BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist This includes other pain relievers, cough-and-cold medicines, or allergy medicines. These medicines may contain additional acetaminophen. Taking too much acetaminophen can be harmful. Ask your pharmacist about the safe use of these products. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY because they may be more sensitive to the effects of the medicine, especially the possible decreased breathing and drowsiness effects. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. THIS MEDICINE IS EXCRETED IN BREAST MILK. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using this medicine, check with your doctor to discuss the risks to your baby.

Percocet Possible Side Effects: SIDE EFFECTS, that may go away during treatment, include nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, flushing, vision changes, or mental/mood changes. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience slow/irregular breathing, slow/irregular heartbeat, or a change in the amount of urine. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

Pain in the body is not a disease on its own, rather, it is an indication or symptom of some other problem or disease. It is very wrong to take pain relievers on your own if you find that your body is aching. Percocet is a narcotic pain reliever and it is a common drug to relive pain. You can get complete cure only if you take appropriate treatment for the disease that actually causes pain.

Just because Percocet 30 mg without prescription is available, you should not try to stock the medicine. The medication must be taken as prescribed by your doctor. It is not advisable to use Percocet longer than necessary and you should not increase the dosage on your own without doctors consent. Overdose of acetaminophen, an important ingredient of Percocet is dangerously harmful for your liver. 
Normally, adults are prescribed 1gm of acetaminophen per dose and a maximum of 4 doses in a day. To ensure that you don’t suffer from constipation while taking the drug, drink lots of water. 

When you buy Percocet 30mg without prescription, you should make sure that it is taken only by those for whom the drug is recommended. Percocet is habit forming and hence, people with a previous history of drug abuse should stay away from it. Dosage of Percocet must be gradually reduced when its time to stop taking it.

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Conventional painkillers might not really work for someone who has a very severe injury. There are prescribed painkillers such as Percocet which are not available over the counter. Percocet is very lethal and should be taken under very specific conditions. Failure to adhere to the dosage and subsequent abuse of the drug is very harmful. You are always advised to never operate heavy machinery or drive because it slows down reaction times

Percocet is a prescription medicine. In some countries, Percocet is considered as a regulated drug. That’s because Percocet is powerful opiate which could trigger dependence if used for extended periods. That’s why you need to consult your physician and ask for proper Percocet prescription so that you can avoid further medical problems. Email Broadmooseheads@gmail.

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Percocet was first manufactured by a German drug manufacturer. Today, Percocet production is broad and you can find it on almost any country. Major drug manufacturers are producing their own branded Percocet which has a very high price tag. Generic Percocet manufacturers on the other hand offer a inexpensive alternative with the same efficacy as the branded ones.

Percocet is a powerful analgesic which controls the pain sensors located in your brain. These pain receptors are made active during a painful event. Through Percocet medication, the chronic pains can be moderated. Your life will certainly develop if you take Percocet daily because you will not feel the pain anymore.

However, there are studies that Percocet is addictive. So it would be best to follow the doses and prescribed dosage of its use. If you did not remember to take Percocet on your regular schedule, don’t compensate by double dosing on your next dosage. You might suffer from overdose which is a very dangerous medical condition. Your doctor will also ask you to gradually reduce your intake if ever you decide to discontinue Percocet medication. Abruptly withdrawing from Percocet may have adverse side effects also.

Chronic pains can be decreased by Percocet medication. It can quickly help you cope with the painful episodes that you experience constantly. Don’t forget however that Percocet is a very powerful drug with addictive active ingredients. That is why you have to take all precautions when undergoing medication of Percocet.

Percocet can be called a perfect solution for people suffering from acute pain. This medicine also contains aspirin which is again a pain reliever. Apart from acting as a pain reliever, it also cures inflammation and fever. Apart from aspirin, Percocet also contains Oxycodone and this combination can be very helpful in treating moderate pain to severe pain. Doctors can prescribe Percocet to the patients who have recently undergone severe surgery or are suffering from severe painful conditions. Such patients can buy Percocet with prescription. Buying this medicine without prescription can affect a person’s health and can also create legal implications. Apart from treating pain, inflammation or fever, this drug can also be used under other medical conditions.

Usually, when you take medicines, it is told that you don’t need to crush them because the risk of its mixture with blood increases. So is the case with Percocet. You must not crush it before consumption since it increases the possibility of overdose.  Not following the proper dose and not taking it with proper prescription results in overdosing of Percocet, which can be dangerous for your health. People can also buy Percocet from online web pharmacies with the prescription. Overdose of this medicine can create dependence and therefore it should be consumed with proper guidance and recommendations.

Also, it should be noted that Percocet is not meant for everyone and people suffering from certain kinds of ailments are completely not the right candidates for Percocet consumption. Because of its nature of causing addiction, Percocet has been placed under controlled substance category.

People often suffer from one of the common ailments called pain. Pain can result due to anything such as fever and sometimes, it can be very severe and beyond control. It is during such situations that people buy Percocet in order to treat and control pains. Percocet is formed of two basic ingredients called acetaminophen and Oxycodone. These active ingredients present in Percocet can work together to provide you complete relief from fever or mainly pain that is uncontrollable.

Although Percocet should be bought only with the prescription but people prefer to buy Percocet online because it can be available without prescription on the online pharmacies. Hence, the risk of being ripped off becomes higher. However, it should be noted that there are many good websites that sell Percocet in a genuine approach and your aim should be buy the medicine from such websites only. In such a regard, it is important to research about the medicine properly and then buy it. Nevertheless, with the advent of Internet, you will find various websites online which allow you to purchase Percocet without prescription.

Unfortunately, it is really not that simple to explain which online pharmacy is genuine and which one is fake. Therefore, it is important that users should themselves be aware about this fact. Also, it is better to buy this medicine with prescription and with proper consultation from your doctor. No doubt, Percocet has the capacity to treat pain in just a few times, but it is still important to consult doctor for right kind of dosage.

Percocet is one of the best medications for relieving strong pain. This statement relies on the mollions of patients who buy it. Probably this can be explained by the effectiveness of Percocet’s components. One of them is Oxycodone which is a strong opioid painkiller which is safer than morphine. Oxycodone is more efficient than Hydrocodone and it can be sold in pure form (like Oxycontin) or in compound with Acetaminophen like Percocet. Such compound makes Percocet safer than pure Oxycodone because the maximum dosage of Percocet is 10/650 (oxycodone/acetaminophen) which is 8 times less than in Oxycontin 80 mg. Oxycodone works on neurotransmitters while acetaminophen, better known as paracetamol reduces fever.

Very significant plus of Percocet is its price. The drug is about 3 times cheaper than pure oxycodone and as cheap as Hydrocodone which is considered weaker.

As for easiness of buying online, Percocet is difficult to be found on the internet. The reason is that it is contolled substance (belonging to schedule II) with high potential to be abused. Be careful if you found a pharmacy which sells percocet. First look at modes of payment. If the parmacy does not offer credit cards don’t deal with such pharmacy. Credit card merchants don’t work with scammers which don’t deliver orders

Well, the question is where to buy percocet online. I must admit that Percocet is the rarest medication among all pain relievers online. Even rogue Pharmacy MedPro doesn’t always have it in stock. I actually don’t know where this pharmacy ships from and if it ships. This pharmacy doesn’t have any main site, it has hundreds of domains. However, it is very easy to identify this pharmacy: its domains are all Ukrainian (ending in ua) and less Russian (ru). If you see any pharmacy with Russian/Ukrainian domain – RUN!!!There is a huge risk that they scam you. Their name was World Pharmacy and there is information on them. Nothing good. Pain relievers cost very expensive so you can waste a lot of money if you try to buy from them! Buy the way, if you spam your email (they spammed mine) you can report spam and make internet safer! In other articles I’ll talk about another well-spread pharma ripoffs but now I want to say that there are a few pharmacies that you can choose when you’re going to buy Percocet online. One of them is my best online drugstore that never rips off.

If you have pain the best solution to relieve it is percocet. This drug contains oxycodone, by the strongest pain reliever and acetaminophen that also relieves pain and reduces fever. Acetaminophen, or paracetamol can be found in anti-flu remedies. Together with opioids they make the strongest pain relief medications. Percocet is the mixture of oxycodone and acetaminophen while Lortab, Lorcet and Vicodin include hydrocodone with acetaminophen in different proportions.

There are many countries where the drugs have the same quality but are less strictly regulated than in the US. I talk primarily about Latin American countries. The world became so narrow these days and you really can buy percocet online without losing quality. Just remember that ordering in bulk is prohibited and you can buy more than a 90-day supply.

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substanced. That means that this can be easily abused if not taken properly. Percocet has two active components, oxycodone and acetaminophen. Oxycodone is effective for eliminating pain and it works in a way similar to codeine featuring such side effects as drowsiness and descreased breath. The other component called acetaminophen can be found in many other non-prescription drugs as it is used to amplify the effect of oxycodone. The main side effect of acetanimophen is the danger of liver failure if its daily consumption exceeds 4000 mg.

It is clear that you should be aware of Percocet’s side effects. Some health conditions such as lung diseases, head injuries, kidney and liver issues and others make use of Percocet dangerous for life.

However, if taking Percocet doesn’t threaten your health then I recommend you to buy Percocet online.
This pharmacy offers Brand Percocet made by Endo Pharmaceuticals and generic versions of this drug. The quality is super and the price is moderate if compared with offline drugstores.

Percocet is a strong medicine for relieving pain. It exists in different variantions. There are 2.5/325, 5/325, 7.5/325, 7.5/500, 10/325, 10/650 dosages of Percocet. The strongest one is 10/650 but it contains more acetaminophen so you should remember about 4000 daily maximum of this component.

Percocet should be taken every six hours. Please keep in mind that you must not have medical conditions when taking Percocet is prohibited. Percocet may also interact with other medications so make sure you don’t take anti-anxiety drugs, other pain medications, barbiturates and Percocet simultaneously.

Percocet 10 mg is probably the most popular dosage of this drug. The maximum amount of of Percocet 10/325 should not exceed 6 pills per day. If you feel you overdosed Percocet please consult your doctor immediately.

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Here I will give my recommendations on buying percocet online. If you have no experience buying things online then ordering on the net may be an adventure for you. If you have already bought different things at online shops or auctions then you must read this to know how buying prescription drugs differs from other products. First, you should know that safety rules are extremely important when buying pills onine because your health is in question.

There are a large number of sites on the net that help customers buy Percocet online. There are even some pharmacies that offer the option of buying this drug without any prescription.

Mild to severe pain may be cured by using the narcotic pain killers. Brain chemicals which cause excessive pain are generally suppressed by relieving tablets and so you will not feel any pain after taking these drugs. Percocet includes acetaminophen and oxycodone and so in case you are anyway allergic to the narcotic medications, it is better to fist consult with your doctor and then decide on whether to use Percocet or not.

As Percocet is highly regulated drug in many countries, it is basically illegal to buy the medication without prescription. This means that you will need to find the pharmacy operating from the nation where selling Percocet without prescription is totally legal. None of the drug stores selling the medication without prescription will meet normal standards like being approved by FDA or having Verified Internet Pharmacy Practice Seal. So, it is best to choose the store that is reliable and renowned when it comes to buying Percocet online.

Although you can easily buy Percocet online without taking prescription from the doctor, it is better to consult the doctor to avoid any ill effects to your health. Patients facing acute health problems pertaining to kidney, liver, lungs and heart should in fact not take the drug without proper medical prescription. In case you take other medications, it is best to let you doctor know about it before you plan to take Percocet.

Oxycondone is a drug that acts as a potential depressant of the Central Nervous system. It is nothing but a narcotic basically much like Vicodin or morphine and is given to relieve the patient from moderate to severe forms of pain such as that experienced during fractures, arthritis, birth of a child or during other serious ailments such as cancer.  It has several brand names such as Percocet, OxyContin, Tylox and Percodan. In form it is an opiate, and the drug is generally referred to as oxy and hillibilly heroin by the laymen. Patients are always encouraged to buy cheap Percocet online these days.
Impacts:
The certain impacts that these drugs have on the body are that of providing a feeling of joy and happiness and bring on a sense of euphoria.  It also helps in pain relief and helps in the prevention of many forms and kinds of withdrawal symptoms when one withdraws oneself from some serious form of addiction or so.  Since it is a very common drug and is used for pain relief it can be taken without the help of doctors also.
Online availability:
There are a lot of stores from which one can buy cheap Percocet without having the prescription of any registered medical practitioner. Off late this facility has also found its way into the Internet medium and can buy the medicine through the Internet without producing any prescription of the doctor. This makes the drug easily available to all but it shouldn’t be misused. By adults and children alike as drug addiction in any form is harmful.

Percocet is the hard to find drug on the net but there are various ways to do that as well. The very first thing you can do to buy Percocet online is to sign up for some membership pharmacy. Probably you may have seen a lot of such drug stores providing Percocet and other drugs at cheap rates. But it is wise to keep into consideration that you buy from the legit and reputable store only.

Also, when planning to buy Percocet online, you need to be aware of everything about the drug like what it treats, how to take it, the health conditions and side effects it may provide.

Going the online way to purchase Percocet is indeed great as it helps to save you money. The online stores and pharmacies offer amazing discounts when you buy Percocet from them. This is further made possible when you buy the drugs in bulk and thus enjoy wholesale discounts. You can check out the various deals and packages available when it comes to buying Percocet on the net. Just make sure that you opt for the best deal so that you do not leave a hole in your kitty.

Whatever you reason may be to buy Percocet online, you need to ensure that you buy only from a trusted and reliable pharmacy. This will ensure that you get quality medicine without causing any negative effects on your body. Percocet online is indeed not that tough to get as there are a number of legitimate sites available.

If you suffer from pain you need a proper medication which will effectively help you get rid of pain. There are plenty of pain medications, both narcotic and non-narcotic. Being non-narcotic does not mean safe, such drugs as Tylenol have various side effects as well.

Many people prefer Percocet as pain reliever. There are several reasons why Percocet is so popular for pain management. First of all, Oxycodone is stronder than Hydrocodone and many patients prefer Oxycodone ad pain reliever. The second benefit is that the combination of Oxycodone and Acetaminophen works perfectly and lesser amount of narcotic is needed. The third advantage is the price as Percocet is similar to Hydrocodone and at least three times cheaper than Oxycodone

Percocet 10 mg no prescription neededKnown as a painkiller, Percocet 10 mg is sometimes provided for patients who have undergone surgical procedure. This is a medication that has been endorsed by the FDA in order to help patients who are undergoing intense pain. While you can buy this drug from nearby drugstores, it is possible to avail of next-day shipment of Percocet from online pharmacy. But before you obtain the positive factors of the medications that are offered in online pharmacies, you have to be aware of some precautionary measures. This kind of information may be obtained through research, your specialist, or from online medical sites.

Before you decide to order and avail of next-day shipment of Percocet 10mg from online pharmacy, it is essential to educate yourself regarding this drug and its effects on your body, especially your central nervous system. The typical side effects of Percocet, which you might feel after taking the drug, include feeling nauseated, lightheaded, and dizzy. What you need to avoid from is mounting forbearance over the drug, especially if you have been taking it for some time. This is the reason why you need to consult with your doctor about the likely side effects of Percocet 5 mg. On the other hand, you can also know more about the different reactions of the body to the medicine by talking to a pharmacist.

Aside from being able to obtain Percocet overnight delivery from online pharmacy, it is possible to order it without needing a prescription. Online pharmacies abroad offer OTC Percocet, which is not provided within U.S. online pharmacies. When you want to be assured of the drug’s quality, you have to opt for prescribed Percocet overnight delivery from online pharmacy. The doctor’s recommendation for the medicine is faxed over to the online pharmacy, from where you will be buying Percocet 5mg. With the rules of the FDA controlling the operation of the pharmacy, you are provided with assurance. Some of these are discounted prices, convenient method of buying medicines, and guaranteed high-quality drugs

Aside from being able to obtain Percocet overnight delivery from online pharmacy, it is possible to order it without needing a prescription. Online pharmacies abroad offer OTC Percocet, which is not provided within U.S. online pharmacies. The first thing that you have to do if you want to order next-day shipment of Percocet from pharmacy on the Internet is to obtain a prescription from your doctor. The written approval for the drug is faxed over to the online pharmacy, from where you will be buying Percocet. As long as the online drugstore is regulated by the FDA, you will be able to acquire several benefits. Some of these are discounted prices, convenient method of buying medicines, and guaranteed high-quality drugs.

Percocet Prescription Pain Medication Info

DESCRIPTION FOR PERCOCET PAIN MEDICATION
Treats moderate to severe pain. Percocet contains Oxycodone and Acetaminophen. Oxycodone which is related to codeine is in a class of prescription drugs called narcotic analgesics. Oxycodone ( generic percocet ) is used for relieving pain and its calming effect. Acetaminophen is a less potent pain reliever that increases the effects of oxycodone. Together, acetaminophen and oxycodone ( percocet ) are used for pain management to relieve moderate-to-severe pain. Percocet tablets (oxycodone with acetaminophen) are often prescribed for post-operative pain control. Percocet pain pills may also be prescribed for other purposes, speak with your doctor or pharmacist for more information.Generic Percocet Name: Oxycodone and Acetaminophen

Brand Name pain pills similiar to percocet: Endocet, Oxycocet, Percocet 10/650 mg, Percocet 2.5/325 mg, Percocet 5/325 mg, Percocet 7.5/500 mg, Percocet-5, Percocet-Demi, Roxicet, Roxilox, Tylox, Percodan, Endodan, Roxipirin

HOW TO USE AND STORE PERCOCET

Your doctor will tell you how much percocet pain medication to take and how often. Take this pain medication exactly as prescribed by your doctor. The usual percocet dose is 1 tablet every 6 hours as needed but doses vary among individuals. Doctors sometimes prescribe a higher dose if necessary.Follow the directions on your percocet prescription label and ask your pharmacist or doctor about anything you do not understand. Do not take more percocet than the doctor prescribed, if the pain is not being sufficiently treated then speak with your doctor. Do not share percocet pain medication with anyone else and be sure to keep these strong painkillers and all other medications out of the reach of children. You should not use percocet pain pills if you have ever had an allergic reaction or if you are sensitive to acetaminophen, percocet, or oxycodone. Store percocet at room temperature, away from heat and moisture.Percocet Tablets/Capsules:
Percocet pain medication may be taken with food or milk to lessen stomach upset.
Take each percocet dosage with a full glass of water.Taking percocet pain pills may cause constipation. Drink plenty of fluids or water (six to eight full glasses a day) to lessen the constipation side effect. Increasing the amount of fiber in your diet can also help to releive constipation.If you miss a percocet dose:
Take the missed percocet dose as soon as possible. Skip the missed dose of percocet if it is almost time for your next dose. You should not use two percocet doses at the same time, do not take a double dose of this medicine.If you overdose on percocet:
Seek emergency medical attention. Symptoms of a Percocet overdose include slow breathing, seizures, dizziness, weakness, loss of consciousness, coma, confusion, tiredness, cold and clammy skin, small pupils, nausea, vomiting, and sweating.DRUGS TO AVOID WHILE TAKING PERCOCET PRESCRIPTION PAIN MEDICATION
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products while taking percocet painkillers. Make sure your doctor knows if you are taking any other medications that could make you drowsy such as sedatives, cold and allergy medicine, sleeping pills, tranquilizers, or muscle relaxants. The most serious interactions affecting Percocet are with drugs that also cause sedation.

The following drugs may lead to dangerous sedation if taken with Percocet: brompheniramine (Dimetane, Bromfed, etc), diphenhydramine (Benadryl, Nytol, Compoz, etc), chlorpheniramine (Chlor-Trimeton, Teldrin, etc), amitriptyline (Elavil), doxepin (Sinequan), fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), belladonna (Donnatal), clidinium (Quarzan), dicyclomine (Bentyl, Antispas), hyoscyamine (Levsin, Anaspaz), ipratropium (Atrovent), propantheline (Pro-Banthine), scopolamine (Transderm-Scop), chlorpromazine (Thorazine), fluphenazine (Prolixin), thioridazine (Mellaril), prochlorperazine (Compazine), phenobarbital (Solfoton, Luminal), amobarbital (Amytal), secobarbital (Seconal), alprazolam (Xanax), diazepam (Valium), lorazepam (Ativan), flurazepam (ProSom), and temazepam (Restoril).

If you are taking any of the medicines, you may not be able to take Percocet pain medication or you may require a dosage adjustment or special monitoring during treatment. Also, watch the acetaminophen content of other over-the-counter and prescription medicines while taking percocet painkillers. Do not take more than 4 grams (4000 milligrams) of acetaminophen per day. Drugs other than those listed here may also interact with Percocet so be sure to talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

PERCOCET WARNINGS
Before taking Percocet, tell your doctor if you have: kidney disease, liver disease, asthma, urinary retention, an enlarged prostate, hypothyroidism, seizures or epilepsy, gallbladder disease; a head injury, Addison’s disease or a history of alcohol or drug addiction. If you have any of the above conditions, you may not be able to take Percocet pain medication or you may require a dosage adjustment or special monitoring during treatment.

Percocet may cause drowsiness or dizziness. Use caution when driving or operating machinery while taking percocet. If you experience drowsiness or dizziness, avoid these and other hazardous activities.
Avoid drinking alcohol while taking Percocet pain meds. Alcohol can add to the drowsiness and dizziness caused by Percocet medication.

Percocet pain pills are in the FDA pregnancy category C. This means that it is not known whether it will harm an unborn baby. If you are pregnant, do not take percocet pain medication without first talking to your doctor.

It is not known whether the pain drug percocet passes into breast milk so if you are breast feeding a baby do not take percocet tablets without first talking to your doctor.
If you are younger than 18 years of age or older than 60 years of age, you may be more likely to experience side effects from percocet therapy. Use extra caution.

PERCOCET SIDE EFFECTS
If you experience any of the following serious side effects, stop taking Percocet and notify your doctor immediately or seek emergency medical attention:
Allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
Slow, weak breathing;
Seizures;
Cold, clammy skin;
Severe weakness or dizziness;
Unconsciousness;
Yellowing of the skin or eyes;
Unusual fatigue, bleeding, or bruising

If you have problems with these less serious percocet side effects, tell your doctor:
Constipation, dry mouth, nausea, vomiting, decreased appetite, dizziness, tiredness, lightheadedness, muscle twitches, sweating, itching, decreased urination, or decreased sex drive

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Become a member to buy percocet online, percocet chronic pain pills, pain meds, percocet mexican pharmacy and many more pain medications and prescription drugs.Percocet no prescription is available on the net. Buying on the web seems very easy and simple and the process is discreet and quick. But you need to be very careful about buying the drugs online. This is so because there are several drugstores that are fake and are there just to make profits, offering low quality drugs to the customers.By buying the drugs online, you get the great benefit of enjoying worldwide shipping. This feature can be enjoyed with various pharmacies that offer Percocet no prescription. It is thus imperative to first consult the doctor and then get prescription of the drug to get it online.Even though Percocet without prescription is available, it is still better to opt for proper prescription by the doctor and then only buy the drug. With supervision and direction of the healthcare provider, you will be able to avoid the side effects that may be caused by taking the drug.Let your healthcare provider know the health conditions you may be suffering from, allergic reactions that you may encounter and other information about your health in order to get a proper prescription for Percocet or any other medication. The healthcare provider will determine your condition and other details and then prescribe you to get Percocet or not.Thus relying on Percocet no prescription is possible these days only with the introduction of online pharmacies and drugstores. So wait no more and get Percocet today to relieve the pain you may be suffering from for long.It is difficult to fully enjoy life if you suffer from pain. You are fullt dependant on medications which relieve pain and help you become an active person. Many of you have experienced how complicated it is to buy those pain relief meds that are as important as food to you.

Buying on the internet seems like a miracle because it is cheap, quick and discreet. However, there are lots of risks when you buy pills online. Some online drugstores are specially created to steal money from your credit card, some don’t send what you’ve ordered and some send fake pills.

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Percocet without prescription is not that easily available. You need to show the prescription to drug stores to get the medication. But there are some pharmacies and stores on the net that offer Percocet no prescription. The best part about getting Percocet through online stores is that they offer discreet packages, bargains and high quality drugs.

The worldwide shipping is another feature that can be enjoyed with online pharmacies offering Percocet without any prescription. It is recommended that you visit the doctor and get proper prescription in order to get Percocet for relieving your pain.

Percocet basically includes combination of acetaminophen and oxycodone. It is seen that acetaminophen is the less potent pain killer which increases oxycodone effects and so getting proper medical prescription is always a better option.

Percocet no prescription is utilized by the patients to stay away from pain that may range from mild to serious. It is advisable to get immediate medical assistance in case you face the allergic reactions with Percocet like breathing difficulties, hives, swelling of tongue, face, throat or lips.

Percocet without prescription is widely taken by the people who either do not have much time to visit the doctor or they feel that they will not face any ill effects if they take Percocet no prescription. While the drug may not offer much serious side effects in some cases, it is better if one visits and consults the medical practitioner before taking any sort of medication.

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Each force of Percocet differentiates from the other in the form of the tablet, size, and the color nevertheless, these safeguards can not be available in corresponding generic products. Buy percocet online without a prescription fifty million Americans are in severe pain dorsal arthritis, injuries, cancer and other incapacities, say to the Dr. Scott Fishman, president of medicine the American academy of the pain. She inclined above to watch with fixedness in my letter, gave hour me to write and she buy percocet online without a prescription offered many voluntarily more symptoms and incapacities, adding frequently that she never had had these problems until the accident although she would have taken a pile from narcotic for other things. Love to be buy percocet online without a prescription able to explode a certain F Ing. OxyContin or alguÌ  n Percocet and buy percocet online without a prescription knowledge that he. The four products of Percocet now available include the amounts following of Percocet and of they acetaminophen, respectively magnesium mg325 of Percocet 25. The point to use these medications is to maintain well controlled pain, therefore the exact doses that any patient requires are not important while they can be maintained comfortable. The second on a Buy percocet online without a prescription hotel in Beverly Hills. Not pío like the bones crujió again within place, although a sudden sweat and a reduction of to their it heart would have felt would say it clearly. It knew because the enthusiasm had left the voice of the nurses. Cheney says the buy percocet online without a prescription trusting USA to the process of peace of the Middle East. Percocet is a narcotic analgesia of schedule II and it is used extensively in clinical practice. Because Percocet contains Percocet and buy percocet online without a prescription tylenol, an overdose of Percocet has the same toxicity of the liver that an overdose of Tylenol. Hardly whereas an opiate person in of long term experimenting of some of their indirect effect negative a little later, can also stop obtaining of the appropriate relevación of pain. It had the patient glance in a graph in her paper clip as he answered. She will begin to work to release pain in near 15 to 30 minutes, buy percocet online without a prescription although she reaches his maximum effect on 1 hour. I fear that she can be that buy percocet online without a prescription is pointed.
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Pronounced: PERK-o-set
Generic ingredients: Acetaminophen Oxycodone hydrochloride
Other brand names: Endocet, Roxicet, Tylox

Why is this drug prescribed?

Percocet, a narcotic analgesic, is used to treat moderate to moderately severe pain. It contains two drugs–acetaminophen and oxycodone. Acetaminophen is used to reduce both pain and fever. Oxycodone, a narcotic analgesic, is used for its calming effect and for pain.

Most important fact about this drug

Percocet contains a narcotic and, even if taken only in prescribed amounts, can cause physical and psychological dependence when taken for a long time.

How should you take this medication?

Percocet may be taken with meals or with milk.

–If you miss a dose…

If you take Percocet on a regular schedule, take it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at once.

–Storage instructions…

Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Percocet.

More common side effects may include:

Dizziness, light-headedness, nausea, sedation, vomiting

You may be able to alleviate some of these side effects by lying down.

Less common or rare side effects may include:

Constipation, depressed feeling, exaggerated feeling of well-being, itchy skin, skin rash, slowed breathing (at higher doses)

Why should this drug not be prescribed?

You should not use Percocet if you are sensitive to either acetaminophen or oxycodone.

Special warnings about this medication

You should take Percocet cautiously and according to your doctor’s instructions, as you would take any medication containing a narcotic. If you have ever had a problem with alcohol addiction, make sure your doctor is aware of it.

If you have experienced a head injury, consult your doctor before taking Percocet. The effects of Percocet may be stronger for people with head injuries, and using it may delay recovery.

If you have stomach problems, such as an ulcer, check with your doctor before taking Percocet. Percocet may hide the symptoms of stomach problems, making them difficult to diagnose and treat.

If you have ever had liver, kidney, thyroid gland, or Addison’s disease (a disease of the adrenal glands), difficulty urinating, or an enlarged prostate, consult your doctor before taking Percocet.

Elderly people or those in a weakened condition should take Percocet cautiously.

This drug may impair your ability to drive a car or operate potentially dangerous machinery. Do not participate in any activities that require full alertness if you are unsure about the drug’s effect on you.

Possible food and drug interactions

when taking this medication

Alcohol may increase the sedative effects of Percocet. You should not take Percocet with alcohol.

If Percocet is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Percocet with the following:

Antispasmodic drugs such as Cogentin, Bentyl, and Donnatal

Major tranquilizers such as Thorazine and Mellaril

Other narcotic painkillers such as Darvon and Demerol

Sedatives such as phenobarbital and Seconal

Tranquilizers such as Xanax and Valium

Special information

if you are pregnant or breastfeeding

It is not known whether Percocet can injure a developing baby or affect a woman’s reproductive capacity. Using any medication that contains a narcotic during pregnancy may cause physical addiction for your newborn baby. If you are pregnant or plan to become pregnant, inform your doctor immediately. As with other narcotic painkillers, taking Percocet shortly before delivery (especially at higher dosages) may cause some degree of impaired breathing in the mother and newborn. It is not known whether Percocet appears in breast milk, possibly harming a nursing infant. If you are breastfeeding use Percocet only under a doctor’s directions.

Recommended dosage

ADULTS

The usual dose is 1 tablet every 6 hours. Doctors sometimes prescribe a higher dose if necessary. The maximum daily dose recommended for each strength is as follows:

7.5 strength: 8 tablets

10 strength: 6 tablets

CHILDREN

The safety and effectiveness of Percocet have not been established in children.

Overdosage

A severe overdose of Percocet can be fatal. If you suspect an overdose, seek medical help immediately.

Symptoms of Percocet overdose may include:

Bluish skin, eyes or skin with yellow tone, cold and clammy skin, decreased or irregular breathing (ceasing in severe overdose), extreme sleepiness progressing to stupor or coma, heart attack, low blood pressure, muscle weakness, nausea, slow heartbeat, sweating, vague bodily discomfort, vomiting

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What you should know before you buy Percocet There are certain things you must know before you buy Percocet. For example, there are certain medications that should never be mixed with this drug. You should be aware that Percocet can cause drowsiness and sleepiness. You should avoid operating any heavy machinery, or engaging in long drives. You should also avoid any situation where drowsiness could potentially endanger yourself or others. There are certain medications that you can also cause drowsiness, and you should be careful about taking them when you are using Percocet. For example, you should avoid buying sleeping pills, muscle relaxers and cold or allergy medicine when you buy Percocet. Be careful not to take Percocet with any alcohol, as this can exacerbate the drowsiness that this drug may cause. You should also avoid and anti-depressants, anxiety medications and treatments for seizures, unless you have consulted your doctor beforehand. You should also consult with your doctor if you are taking any other forms of narcotic pain medicines before you buy Percocet. Before you buy Percocet online or elsewhere, you should inform your doctor if you are taking any bladder medications or any urinary medications such as darifenacin (Enablex), solifenacin (Vesicare), flavoxate (Urispas), oxybuntin (Ditropan, Oxytrol) or tolterodine (Detrol). Percocet can affect the urinary tract and the urinary process, so these medications can cause complications. You should also inform your doctor if he prescribes you Percocet and you suffer from irritable bowel syndrome and are taking medication for it. Any of the following treatments for irritable bowel syndrome can interact unfavourably with Percocet, including propantheline (Pro-Banthine), hyoscyamine (Anaspaz, Levsin, Cystospaz). You should not buy Percocet online or locally without first consulting your doctor if you are taking any bronchodilators such as tiotropium (Spiriva) or ipratropium (Atrovent). You should also seek advice before you buy Percocet online or elsewhere if you are taking any of the following medications – mepenzolate (Cantil), benztropine (Cogentin), methscopolamine (Pamine), glycopyrrolate (Robinul), scopolamine (Transderm-Scop), atropine (Donnatal) and dimenhyrdinate (Dramamine). To be completely safe, inform your doctor of any and all medications that you take before you buy Percocet. This includes all supplements, herbal tablets, mineral tablets, vitamins, any prescription drugs and any other over-the-counter medications that you may use. After you buy Percocet, you must be careful to stick to your prescription precisely. Never take more than 4 grams of Percocet per day. Overdosing with Percocet can be very serious, and potentially fatal. The symptoms of an overdose include dark urine, weakness or fainting, the narrowing of the pupils, disorientation and severe drowsiness. You may also experience extreme vomiting or nausea, blue lips and shallow breathing. Coma is a potential result, as is muscle weakness, cold skin and jaundice. If you experience any of these symptoms you must seek medical help immediately.

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Step 2: Find an Online Pharmacy

After you have a valid prescription, you need to find an online pharmacy to fill it and send the Percocet to you. You have to give your bank account or credit card information to them and you have to trust them to send you an authentic supply of Percocet. You should do complete research of the company you send your information to, before you allow them to fill the prescription. This research can help to make sure the pharmacy you choose is operating inside the law.4

Find an Approved Online Pharmacist – There are a number of websites you can go to for your Percocet, but you have to be careful about the website you choose to do business with. A reputable online pharmacist will be a member of the Verified Internet Practice Sites, (VIPS) and The National Association of Boards of Pharmacies (NABP)6

Make Sure the Percocet is Not From Outside The USA – If you live inside the United States, it is considered a crime to receive prescription drugs from foreign a country. There have been reports of online pharmacies filling prescriptions with something other than Percocet. The fake drugs, when taken, can cause serious health problems. 7

Guard Yourself Against Online Identity Theft – Several of the websites that sell Percocet are not a legitimate online pharmacy, be careful of disclosing your personal information.8

After you have decided on an online pharmacy to fill your prescription, you can go to the following step that outline, in detail, you how get the prescription filled.

Step 3: Getting Your Prescription Filled

There are three different strengths and three different forms of Percocet – capsules, pills or liquid. Percocet pills should not be broken or chewed. Capsules can be opened and sprinkled onto apple sauce or pudding and swallowed, without chewing. If you do chew the pills or capsules, this changes the chemical make-up of the medicine and causes it to be released into your system differently.9

Always drink a glass of water with your dose to prevent acute constipation and never take more medicine than you are prescribed. When you order Percocet from a reputable online pharmacy, you can rest assured, it will be authentic.9 The Rite Aid, CVS, Walgreens and WalMart websites have a registered online pharmacy that will fill your prescription for you. If you have decided to order from a pharmacy, other than these that are recommended above, before you send in your payment information, there are some guidelines to follow to ensure your complete satisfaction.

Information is available on the Federal Drug Administration website about the dangers of buying medically prescribed drugs, with or without a prescription.

Get your doctor to Fax your prescription and talk to the online pharmacist, to get your prescription filled. There are some unscrupulous pharmacists who will send you fake drugs that may not be safe for you to take. But, if you want to buy Percocet online without a prescription, there are a number of websites that will agree to send you some ‘Percocet’.10

Do other drugs affect Percocet in the system? – There are several drugs that will cause a bad reaction, if they are taken with Percocet or if you have any traces of them in your system. If you use, or have used any of the drugs listed below, within the last 14 days, you should tell your doctor.

  • Antidepressants
  • MAO Inhibitor
  • Bladder medication
  • Excessive alcohol

You should also discuss with your doctor if you have problems with:

  • Addison’s Disease
  • Mental illness
  • Liver of kidney disease
  • Seizures
  • Prostate problems
  • Curvature of the spine
  • Problems with drug addiction

If you have any of the problems listed, avoid taking Percocet until you talk with a professional. All drugs should be kept out of the reach of children and they should be taken according to instructions.

Step 2: Find an Online Pharmacy

After you have a valid prescription, you need to find an online pharmacy to fill it and send the Percocet to you. You have to give your bank account or credit card information to them and you have to trust them to send you an authentic supply of Percocet. You should do complete research of the company you send your information to, before you allow them to fill the prescription. This research can help to make sure the pharmacy you choose is operating inside the law.4

Find an Approved Online Pharmacist – There are a number of websites you can go to for your Percocet, but you have to be careful about the website you choose to do business with. A reputable online pharmacist will be a member of the Verified Internet Practice Sites, (VIPS) and The National Association of Boards of Pharmacies (NABP)6

Make Sure the Percocet is Not From Outside The USA – If you live inside the United States, it is considered a crime to receive prescription drugs from foreign a country. There have been reports of online pharmacies filling prescriptions with something other than Percocet. The fake drugs, when taken, can cause serious health problems. 7

Guard Yourself Against Online Identity Theft – Several of the websites that sell Percocet are not a legitimate online pharmacy, be careful of disclosing your personal information.8

After you have decided on an online pharmacy to fill your prescription, you can go to the following step that outline, in detail, you how get the prescription filled.

Step 3: Getting Your Prescription Filled

There are three different strengths and three different forms of Percocet – capsules, pills or liquid. Percocet pills should not be broken or chewed. Capsules can be opened and sprinkled onto apple sauce or pudding and swallowed, without chewing. If you do chew the pills or capsules, this changes the chemical make-up of the medicine and causes it to be released into your system differently.9

Always drink a glass of water with your dose to prevent acute constipation and never take more medicine than you are prescribed. When you order Percocet from a reputable online pharmacy, you can rest assured, it will be authentic.9 The Rite Aid, CVS, Walgreens and WalMart websites have a registered online pharmacy that will fill your prescription for you. If you have decided to order from a pharmacy, other than these that are recommended above, before you send in your payment information, there are some guidelines to follow to ensure your complete satisfaction.

Information is available on the Federal Drug Administration website about the dangers of buying medically prescribed drugs, with or without a prescription.

Get your doctor to Fax your prescription and talk to the online pharmacist, to get your prescription filled. There are some unscrupulous pharmacists who will send you fake drugs that may not be safe for you to take. But, if you want to buy Percocet online without a prescription, there are a number of websites that will agree to send you some ‘Percocet’.10

Do other drugs affect Percocet in the system? – There are several drugs that will cause a bad reaction, if they are taken with Percocet or if you have any traces of them in your system. If you use, or have used any of the drugs listed below, within the last 14 days, you should tell your doctor.

  • Antidepressants
  • MAO Inhibitor
  • Bladder medication
  • Excessive alcohol

You should also discuss with your doctor if you have problems with:

  • Addison’s Disease
  • Mental illness
  • Liver of kidney disease
  • Seizures
  • Prostate problems
  • Curvature of the spine
  • Problems with drug addiction

If you have any of the problems listed, avoid taking Percocet until you talk with a professional. All drugs should be kept out of the reach of children and they should be taken according to instructions.

Medical uses

Oxycodone is effective for managing moderate to moderately severe acute or chronic pain.[7] It has been found to improve quality of life for those with many types of pain.[8]

Oxycodone can also be used as a alternative to other opiates to treat severe diarrhea and diarrhea predominant irritable bowel syndrome when drugs such as loperamide and diphenoxylate are ineffective.

In 2001, the European Association for Palliative Care recommended that oral oxycodone be a second-line alternative to oral morphine for cancer pain.[9] There is no evidence that any opioids are superior to morphine in relieving the pain of cancer, and no controlled trials have shown oxycodone to be superior to morphine.[10]

[edit] Adverse effects

Main side effects of oxycodone[11]

The most commonly reported effects include memory loss, constipation, fatigue, dizziness, nausea, lightheadedness, headache, dry mouth, anxiety, pruritus, and diaphoresis.[12] It has also been claimed to cause dimness in vision due to miosis. Some patients have also experienced loss of appetite, nervousness, abdominal pain, diarrhea, ischuria, dyspnea, and hiccups,[2] although these symptoms appear in less than 5% of patients taking oxycodone. Rarely, the drug can cause impotence, enlarged prostate gland, and decreased testosterone secretion. Compared to morphine, oxycodone causes less respiratory depression, sedation, pruritus, and nausea.[13] As a result, it is generally better tolerated than morphine.[14]

In high doses, overdoses, or in patients not tolerant to opiates, oxycodone can cause shallow breathing, bradycardia, cold, clammy skin, apnea, hypotension, miosis (pupil constriction), circulatory collapse, respiratory arrest, and death.[2]

[edit] Withdrawal

There is a high risk of experiencing severe withdrawal symptoms if a patient discontinues oxycodone abruptly. Therefore therapy should be discontinued gradually rather than abruptly. People who use oxycodone in a hazardous or harmful fashion are at even higher risk of severe withdrawal symptoms as they tend to use higher than prescribed doses. The symptoms of oxycodone withdrawal are the same as for other opiate based painkillers and may include “anxiety, panic attack, nausea, insomnia, muscle pain, muscle weakness, fevers, and other flu like symptoms.”[15]

Withdrawal symptoms have also been reported in newborns whose mothers had been either injecting or orally taking oxycodone during pregnancy.[16]

[edit] Detection in biological fluids

Oxycodone and/or its major metabolites may be quantitated in blood or urine to monitor for abuse, confirm a diagnosis of poisoning or assist in a medicolegal death investigation. Many commercial opiate screening tests cross-react appreciably with oxycodone and its metabolites, but chromatographic techniques can easily distinguish oxycodone from other opiates.[17]

[edit] Pharmacology

[edit] Mechanism of action

A group of Australian researchers has proposed (based on a 1997 study in rats) that oxycodone, unlike morphine (the effect of which is mediated by μ-opioid receptors), acts on κ-opioid receptors.[18] Further research by this group indicates the drug appears to be a κ2b-opioid agonist.[19] However, this has been disputed, primarily on the basis that oxycodone produces effects typical of μ-opioid agonists.[20]

Research by a Japanese group suggests that the effect of oxycodone is mediated by different receptors in different situations. Specifically, in diabetic mice the κ-opioid receptor appears to be involved in the antinociceptive effects of oxycodone,[21] while in non-diabetic mice the μ1-opioid receptor seems to be primarily responsible for these effects.[22]

[edit] Absorption

After a dose of conventional oral oxycodone, peak plasma levels of the drug are attained in approximately one hour;[3] in contrast, after a dose of OxyContin (an oral continuous release formulation), peak plasma levels of oxycodone occur in about three hours.[2]

[edit] Distribution

Oxycodone in the blood is distributed to skeletal muscle, liver, intestinal tract, lungs, spleen, and brain.[2] Conventional oral preparations of oxycodone start to reduce pain within 10–15 minutes; in contrast, OxyContin starts to reduce pain within 1 hour.[7]

[edit] Metabolism

Oxycodone is metabolized to α and β oxycodol; oxymorphone, then α and β oxymorphol and noroxymorphone; and noroxycodone, then α and β noroxycodol and noroxymorphone (N-desmethyloxycodone).[3] (14-Hydroxydihydrocodeine that in turn becomes 14-Hydroxydihydromorphine) These metabolites are true only for humans.[23] As many as six metabolites for oxycodone (14-hydroxydihydromorphinone, 14-hydroxydihydrocodeine, 14-hydroxydihydrocodeinone N-oxide {oxycodone N-oxide}, 14-hydroxydihydroisocodeine, 14-hydroxydihydrocodeine N-oxide, and noroxycodone) have been found in rabbits,[24] several of which are thought to be active metabolites to some extent, although a study using conventional oral oxycodone concluded that oxycodone itself, and not its metabolites, is predominantly responsible for the drug’s opioid effects on the brain.[3]

Unlike morphine and hydromorphone, oxycodone is metabolized by the cytochrome P450 enzyme system in the liver, making it vulnerable to drug interactions.[2] Some people are fast metabolizers resulting in reduced analgesic effect but increased adverse effects, while others are slow metabolisers resulting in increased toxicity without improved analgesia.[25][26] The dose of OxyContin must be reduced in patients with reduced hepatic function.[7]

[edit] Elimination

Oxycodone and its metabolites are mainly excreted in the urine and sweat; therefore, it accumulates in patients with renal impairment.[7]

[edit] Dosage and administration

Oxycodone can be administered orally, intranasally, via intravenous/intramuscular/subcutaneous injection or rectally. The bioavailability of oral administration of Oxycodone averages 60–87%, with rectal administration yielding the same results; intranasal varies between individuals with a mean of 46%.[27]

Oxycodone is approximately 1.5–2 times as potent as morphine when administered orally.[28][29] However, 10–15 mg of oxycodone produces an analgesic effect similar to 10 mg of morphine when administered intramuscularly.[30] Therefore, as a parenteral dose, morphine is approximately up to 50% more potent than oxycodone.

There are no comparative trials showing that oxycodone is more effective than any other opioid. In palliative care, morphine remains the gold standard;[10] however, oxycodone can be useful as an alternative opioid if a patient has troublesome adverse effects with morphine.

[edit] Chemistry

Oxycodone’s chemical name is derived from codeine. The chemical structures are very similar, differing only in that

  • Oxycodone has a hydroxyl group at carbon-14 (codeine has just a hydrogen in its place), hence oxycodone;
  • Oxycodone has a 7,8-dihydro feature, whereas codeine has a double bond between those two carbons; and
  • Oxycodone has a carbonyl group (as in ketones) in place of the hydroxyl group of codeine, hence the “-one” suffix.

It is also similar to hydrocodone, differing only in that it has a hydroxyl group at carbon-14.[7]

Expanded expression for the compound oxycodone in the academic literature include “dihydrohydroxycodeinone”,[4][31][32] “Eucodal”,[31][32] “Eukodal”,[1][33] “14-hydroxydihydrocodeinone”,[4][31] and “Nucodan”.[31][32] In a UNESCO convention, the translations of “oxycodone” are oxycodon (Dutch), oxycodone (French), oxicodona (Spanish), الأوكسيكودون (Arabic), 羟考酮 (Chinese), and оксикодон (Russian).[34] The word “oxycodone” should not be confused with “oxandrolone”, “oxazepam”, “oxybutynin”, “oxytocin”, or “Roxanol”.[35]

[edit] History

Freund and Speyer of the University of Frankfurt in Germany first synthesized oxycodone from thebaine in 1916,[6] a few years after the German pharmaceutical company Bayer had stopped the mass production of heroin due to hazardous use, harmful use, and dependence. It was hoped that a thebaine-derived drug would retain the analgesic effects of morphine and heroin with less dependence. To some extent this was achieved, as oxycodone does not have the same immediate effect as heroin or morphine nor does it last as long.

The first clinical use of the drug was documented in 1917, the year after it was first developed.[6][33] It was first introduced to the US market in May 1939. In early 1928, Merck introduced a combination product containing scopolamine, oxycodone, andephedrine under the German initials for the ingredients SEE, which was later renamed Scophedal (SCOpolamine ePHEDrine & eukodAL)—this combination is essentially an oxycodone analogue of the morphine-based Twilight Sleep with ephedrine added to reduce circulatory and respiratory effects.

The International Narcotics Control Board estimates that 11.5 tons (23,000 lbs) of oxycodone were manufactured worldwide in 1998,[36] by 2007 this figure had grown to 75.2 tons (150,400 lbs).[36] Of all countries, the United States had the highest total consumption of oxycodone in 2007 at 51.6 tons (103,200 lbs) or 82% of the world total. This translates into over half a billion 80 mg tablets per year.[36] In addition, the U.S. had the highest per capita consumption of oxycodone, followed by Canada in 2006, 2007 and 2008. This makes the consumption of oxycodone in North America (United States and Canada alone) higher than all other countries of the world combined. The United States and Canada are consistently ranked among the top two or three in most type of opioid consumption per capita (for example, in 2006 Canada ranked second and the U.S. ranked third in morphine consumption per capita; only Austria ranked higher and that is due to the fact that in addition to being used to treat moderate to severe pain, morphine is also used to treat heroin or morphine dependence in Austria – a practice which is unheard of in North America).[36][37]

[edit] Brand names

All brand-names not marked otherwise are standard-release tablets or capsules of oxycodone without further pharmacologically active ingredients.

  • Dinarkon (Germany)
  • Diphydrone
  • Endocet (US) (compounded with paracetamol)—by Endo
  • Endodan (US) (compounded with acetylsalicylic acid)—by Endo
  • ETH-Oxydose (US)
  • Endone (US)—by Endo
  • Eukodal (Germany) (for injection)
  • OxyContin (US) (modified release)—by Purdue Frederick
  • OxyFast (US) (oral liquid)
  • OxyNorm (US) (tablets, oral liquid, liquid for injection)
  • OxyNormoro (France)—by Mundipharma
  • Pancodine
  • Percodan (US) (compounded with acetylsalicylic acid)—by Endo
  • Percodan-Demi (US) (compounded with acetylsalicylic acid)—by Endo
  • Percocet (US) (compounded with paracetamol)—by Endo
  • Percolone (US)—by Endo
  • Roxicet (US)—by Roxane
  • Roxicodone (US)—by Roxane
  • Roxilox (US)—by Roxane
  • Roxiprin (US) (compounded with acetylsalicylic acid)—by Roxane
  • Supeudol (Canada)—by Sandoz
  • Thekodin (Germany)
  • Tylox (US)

[edit] OxyContin

OxyContin is the brand name of a time-release formula of oxycodone produced by the pharmaceutical company Purdue Pharma.[38] It was approved by the U.S. Food and Drug Administration in 1995 and first introduced to the U.S. market in 1996.[38] By 2001, OxyContin was the best-selling non-generic narcotic pain reliever in the U.S.; 2008 sales in the U.S. totaled $2.5 billion.[39] An analysis of data from the U.S. Drug Enforcement Administration found that retail sales of oxycodone “jumped nearly six-fold between 1997 and 2005.”[40] Mundipharma distributes OxyContin in Australia,[41] China,[42] and Europe.[43]

In 2001, Purdue Pharma permanently suspended distribution of 160 mg tablets in the U.S. because of the “possibility of illicit use of tablets of such high strength.” It is speculated that the DEA had requested Purdue to discontinue manufacturing the 160 mg Tablets, however the DEA has publicly denied asking Purdue to do so.[38][44] Beginning in 2010, the brand name OxyContin by Purdue was reformulated to prevent the misuse and abuse of the tablets. Additional binders have been added to prevent the grinding of tablets for insufflation or injection, and to maintain OxyContin’s extended release characteristics.[45] These new tablets are more often prescribed by physicians than previous generic versions for this exact purpose and bear the stamp ‘OP’ instead of the previous ‘OC.’

[edit] Lawsuits concerning generics

Purdue has multiple patents for OxyContin, but has been involved in a series of ongoing legal battles on the validity of these patents. On June 7, 2005, the United States Court of Appeals for the Federal Circuit upheld a decision from the previous year that some of Purdue’s patents for OxyContin could not be enforced.[46] This decision allowed and led to the immediate announcement from Endo Pharmaceuticals that would begin launching a generic version of all four strengths of OxyContin.[47] Purdue, however, had already made negotiations with another pharmaceutical company (IVAX Pharmaceuticals) to distribute their brand OxyContin in a generic form.[47] This contract was severed, and as of October 2005 Watson Pharmaceuticals became the exclusive U.S. distributor of Purdue-manufactured generic versions of OxyContin tablets in 10-, 20-, 40-, and 80-milligram dosages.[48]

On February 1, 2006, the Federal Circuit Court of Appeals issued a decision revising its 2005 decision.[49] This time the court vacated the lower court’s “judgment that the patents-in-suit are unenforceable due to inequitable conduct,” and the case was “remanded for further proceedings.”[49]

Purdue Pharma has since announced resolution of its infringement suits with Endo,[50] Teva,[51] IMPAX,[52] and Mallinckrodt.[53] Endo and Teva each agreed to cease selling generic forms of OxyContin.[50][51] IMPAX negotiated a temporary, and potentially renewable, license.[52] In 2008, Mallinckrodt Pharmaceuticals reintroduced generic OxyContin in the strengths of 10 mg, 20 mg, 40 mg and 80 mg, which was made possible by a temporary royalties-bearing license with Purdue Pharma that expired in 2009.[53]

[edit] Marketing and misbranding

Critics have accused Purdue Pharma of putting profits ahead of public interest by applying “significant political pressure” to attempt to reverse South Carolina’s requiring prior approval before a person with Medicaid can receive the drug;[54] for “fail[ing] to adequately warn consumers of the risks” of OxyContin such as dependence;[55] and for promoting the drug “aggressively” and by means such as “promotional beach hats, pedometers and swing-music CDs.”[55][56]

In May 2007 Purdue Pharma “agreed to pay $19.5 million” in fines relating to aggressive off-label marketing practices of OxyContin in 26 states and the District of Columbia.[57] In specific, the company encouraged dosing more frequent than the recommended interval of 12 hours, and did not fully disclose the risk of hazardous or harmful use.[57]

Later in May 2007 Purdue Pharma and three of its top executives pleaded guilty in a Virginia federal court to charges that they misbranded OxyContin by representing it to have “less euphoric effect and less abuse potential” than it actually has, and by claiming that people taking the drug at low doses could stop taking it suddenly without symptoms of withdrawal.[58] The FDA had not approved these claims.[59] The company and the executives were to pay $634 million in fines for felony and misdemeanor misbranding.[58]

In October 2007, officials in Kentucky filed a lawsuit against Purdue Pharma for misleading health care providers and consumers “regarding the appropriate uses, risks and safety of OxyContin”; as of mid-2008, however, the case had been “consolidated with other lawsuits into a single multi-litigation suit” in a federal court in New York.[60]

[edit] Other preparations

Xanodyne pharmaceutical 30mg roxycodone immediate release tablet

Oxy·IR immediate-release oxycodone tablets from Purdue Pharma in Canada are available in 5, 10, and 20 mg strengths.[61] Effective August 10, 2009, Purdue discontinued manufacture and distribution of OxyIR Capsules.

OxyNorm is available in 5, 10, and 20 mg capsules, and also as a 5 mg/5 ml liquid in 250 ml bottles in Australia, New Zealand, the Netherlands and the UK.[62][63][64] In addition, OxyNorm is available in a 10 mg/ml liquid concentrate for oral use in the Netherlands and the UK, and in 10 mg/ml solutions and 50 mg/ml solutions for injection or infusion in New Zealand, the Netherlands and the UK.[64][65] It is also available in Australia as Endone, a generic 5 mg tablet.

Percocet (oxycodone with paracetamol/acetaminophen) tablets are available in Canada and the U.S. with 2.5, 5, 7.5, and 10 mg of oxycodone and varying amounts of acetaminophen.[66]

Depalgos (oxycodone with paracetamol) tablets are marketed in Italy, with 325 mg Paracetamol and 5, 10, and 20 mg oxycodone. Recent legislation in Italy has made it easier for physicians to prescribe this medication and other opioids to pain patients.[67]

Percodan tablets available in the U.S. contain 4.8355 mg of oxycodone HCl and 325 mg of aspirin.[68]

Proladone suppositories, available in Australia, contain 30 mg of oxycodone pectinate.[69]

Roxicodone, a generic oxycodone product designed to have an immediate release effect. The “R” in roxycodone stands for rapid, which is the only difference.It is available in 5 mg (white), 15 mg (green), and 30 mg (blue) tablets; in a 5 mg per 5 ml oral solution; and in a 20 mg per ml liquid concentrate.[70][71] On March 31, 2009, the U.S. Food and Drug Administration directed Boehringer Ingelheim Roxane and Xanodyne Pharmaceuticals to cease manufacture and distribution of 5 mg Roxicodone tablets in the U.S. because they lacked proper approval.[72] In the US Oxycodone Immediate Release tablets are also available in 10 mg (pink) and 20 mg (grey) tablets from KVK-Tech, a generic manufacturer. Targin is a tablet with a prolonged-release oxycodone/naloxone combination.

[edit] Recreational use

General Info

Although it is a semi-synthetic opioid that is closer to codeine in chemical structure and shares much of the same basic opioid effects that are typical of morphine and heroin intoxication, oxycodone misuse often lacks the strong taboos, stigma and negative reputation which heroin and morphine have accrued over the past century – for morphine, two centuries.[73][74] Morphine and heroin’s reputations have developed over a period of more than a century of explosive worldwide abuse and overdose deaths – first morphine, followed in the mid-1900′s by heroin, which is a prodrug or ester salt of morphine with the chemical name di-acetyl-morphine or morphine diacetate.[75][76][77] Lacking this kind of history of abuse and overdose deaths, along with the fact that it is commonly prescribed and put together with the fact that it is not associated with morphine as much as it is associated with codeine or thebaine, many people that would turn away from using because they recognize and associate the words “morphine” or “heroin” with addiction, needles, and disease, wouldn’t associate oxycodone with such and are thus far more likely to use the drug without the same fear or knowledge that it may be able to cause a morphine-like dependence.[74] Another thing that separates oxycodone from morphine or heroin and makes it very appealing to youth, novice drug users, or those that wouldn’t use heroin or morphine is the ease in which it can be used or administered. Most oxycodone users simply use the drug orally or crush the pills into a fine powder and snort it. Using morphine/heroin orally or intranasally is very rare among addicts because of very poor bioavailability by these routes.[78] Instead, those addicted to morphine or heroin must use the drugs by injection, most often IV injection in order to get the full effects of the drug. Another thing that makes oxycodone appealing is the fact that it is a pharmaceutical drug that unlike street heroin or raw opium products, is clean and pure and has a definite amount which is known to the user. This reduces the risk of disease and overdose substantially, as the user won’t have to deal with impurities, needles, and above all, the user can adjust the amount that he or she would like to use.[74] With street heroin it is impossible to know the exact purity or what the drug has been “cut” with and with raw opium products it is impossible to know exactly the amount of morphine that is contained in the opium. Although morphine makes up anywhere from 10% to 15% of dried raw opium, raw opium also contains codeine and other active or non-active ingredients, some of which may have negative effects on the kidneys, liver, lungs, and heart.[79]

Mallinckrodt brand 30mg Generic.

Australia

The illegal use of OxyContin began in Australia in the early 2000s. By 2007, 51% of a national sample of injection drug users in Australia had reported using oxycodone, and 27% had injected it in the last six months.[80]

Oxycodone 5 mg with Acetaminophen (paracetamol) 325 mg formulation by TevaCanada pharmaceuticals; generic form of Percocet.

Canada

Deaths from opioid pain relievers increased from 13.7 deaths per million residents in 1991 to 27.2 deaths per million residents in 2004, which may be related to the spread of OxyContin.[81] After the United States, Canada was the world’s largest per capita consumer of oxycodone in 2006, 2007, and 2008. The per capita consumption of oxycodone in Canada and the U.S. together is higher than all other countries of the world combined.[36][37] The abuse of oxycodone in Canada, particularly the OxyContin formulation has become a very severe problem. Areas where oxycodone is most problematic are Atlantic Canada and Ontario, where its abuse is rampant in rural towns and in many smaller to medium sized cities it has become more readily available than heroin.[82] Although abuse of the drug is seen among all age groups, in Toronto, oxycodone is more rampant in the suburbs and among those under the age of 30, while heroin remains the main opioid of abuse among those over the age of 30, the homeless, and among those that reside in the inner city where Toronto’s street gangs control the distribution of heroin. However, despite the obvious problems with opioids of all kind, cocaine, especially crack cocaine is the biggest drug threat in Toronto.[83][84] Oxycodone is also widely available across Western Canada, but here methamphetamine and heroin are far more serious problems in the larger cities, while oxycodone is very common in rural towns. Oxycodone is diverted through doctor shopping, prescription forgery, pharmacy theft, and over-prescribing.[82][85]

United Kingdom

Hazardous use, harmful use and diversion of OxyContin in the UK commenced in the early- to mid-2000s.[86] The first known death due to OxyContin overdose in the UK occurred in 2002.[87]

United States

The United States was the world’s largest consumer of oxycodone per capita in 2006, 2007, and 2008.[36][37] Instances of recreational use and diversion of OxyContin have increased in the U.S. beginning in the late 1990s.[88] The slang term hillbilly heroin (which originally referred to hydromorphone) for OxyContin refers to the occurrence of the “earliest reported cases of Oxycontin abuse” in the U.S. in rural areas such as Appalachia.[89] Diversion of OxyContin in the U.S. may occur through “fraudulent prescriptions, doctor shopping, over-prescribing, and pharmacy theft.”[88]

A 2003 study by the Government Accountability Office found three factors that may have contributed to the illicit use and distribution of OxyContin in the U.S.:[38]

  • OxyContin contains a large amount of oxycodone compared with other types of oxycodone containing pills.
  • OxyContin’s warning label said to not crush the controlled-release tablets because of the potential for rapid release of oxycodone, which led to many people crushing the tablets and injecting or snorting the drug.
  • By 2001, sales of OxyContin in the U.S. exceeded $1 billion per year.

A study published in 2005 examined the prevalence of opiate analgesic use among “recreational drug users and street addicts” as perceived by “key informants” throughout the U.S.; the authors found that non-clinical use of opiates was increasing in general, but that of the drugs studied use of OxyContin “was mentioned most frequently.”[90] Purdue Pharma has attempted to reformulate the 10–40 mg strengths of OxyContin to prevent the release of a high percentage of the oxycodone by crushing; however, in 2008 a joint panel convened by the U.S. Food and Drug Administration was “concerned that abusers could find a way to manipulate the new formulation.”[91] In 2010, Purdue Pharma introduced ‘Oxycontin OP’, Purdue Pharma predicts that abuse of higher dose formulations such as ‘OxyContin’ will go down, but this change may cause heavy recreational users to resort to other drugs such as heroin or may increase the number of deaths caused by acetaminophen poisoning from users attempting to take similar doses of drugs like ‘Percocet’ or ‘Vicodin’ to get similar effects. Since ‘Oxycontin OP’ has now fully saturated the street markets, recreational users find it nearly impossible to find the original Oxycontin formulations.

One investigation in Boston found that OxyContin was a “gateway” drug for heroin, which addicts turned to as a cheaper alternative.[92]

[edit] Legal status

Oxycodone is subject to international conventions on narcotic drugs. In addition, oxycodone is subject to national laws that differ by country. The 1931 Convention for Limiting the Manufacture and Regulating the Distribution of Narcotic Drugs of the League of Nations included oxycodone.[93] The 1961 Single Convention on Narcotic Drugs of the United Nations, which replaced the 1931 convention, categorized oxycodone in Schedule I.[94] Global restrictions on Schedule I drugs include “limit[ing] exclusively to medical and scientific purposes the production, manufacture, export, import, distribution of, trade in, use and possession of” these drugs; “requir[ing] medical prescriptions for the supply or dispensation of [these] drugs to individuals”; and “prevent[ing] the accumulation” of quantities of these drugs “in excess of those required for the normal conduct of business.”[94]

Australia

Oxycodone is in Schedule I (derived from the Single Convention on Narcotic Drugs) of the Commonwealth’s Narcotic Drugs Act 1967.[95] In addition, it is in Schedule 8 of the Australian Standard for the Uniform Scheduling of Drugs and Poisons (“Poisons Standard”), meaning that it is a “controlled drug… which should be available for use but require[s] restriction of manufacture, supply, distribution, possession and use to reduce abuse, misuse and physical or psychological dependence.”[96]

Canada

Oxycodone is a controlled substance under Schedule I of the Controlled Drugs and Substances Act (CDSA).[97] Every person who seeks or obtains from a practitioner either the substance or an authorization to obtain the substance must disclose to that practitioner information on all controlled substances and authorizations for controlled substances obtained from any other practitioner within the preceding 30 days; otherwise, the person may be found “guilty of an indictable offence and liable to imprisonment for a term not exceeding seven years”.[97] Anyone possessing the substance for the purpose of trafficking “is guilty of an indictable offence and liable to imprisonment for life”.[97]

Germany

The drug is in Appendix III of the Narcotics Act (“Betäubungsmittelgesetz” or BtMG).[98] The law states that only physicians, dentists and veterinarians (“Ärzte, Zahnärzte und Tierärzte”) can prescribe oxycodone, and that the federal government can regulate the prescriptions (e.g., by requiring reporting).[98]

Hong Kong

Oxycodone is regulated under Part I of Schedule 1 of Hong Kong’s Chapter 134 Dangerous Drugs Ordinance.[99] The penalty for trafficking (Section 4) or manufacturing (Section 6) the substance is a $5,000,000 HKD fine and/or life imprisonment.[99] In Section 8 of the Ordinance, possession of the substance for consumption without licence from the Department of Health is illegal and subject to a $1,000,000 HKD fine and/or 7 years of imprisonment.[99] Per Sections 22–23, only specific health professionals and others (e.g., “a person in charge of a laboratory used for the purposes of research”) may possess and supply the substance.[99] Anyone who supplies the substance without a valid prescription can be fined $10,000 HKD according to Section 31.[99]

Singapore

Oxycodone is listed as a Class A drug in the Misuse of Drugs Act of Singapore, which means that offences in relation to the drug attract the most severe level of punishment. A conviction for unauthorized manufacture of the drug attracts a minimum sentence of ten years’ imprisonment and corporal punishment of five strokes of the cane, and a maximum sentence of life imprisonment or 30 years’ imprisonment and 15 strokes of the cane.[100] The minimum and maximum penalties for unauthorized trafficking in the drug are respectively five years’ imprisonment and five strokes of the cane, and 20 years’ imprisonment and 15 strokes of the cane.[101]

United Kingdom

Oxycodone is a Class A drug under the Misuse of Drugs Act.[102] For Class A drugs, which are “considered to be the most likely to cause harm,” possession without a prescription is punishable by up to seven years in prison, an unlimited fine, or both.[103] Dealing of the drug illegally is punishable by up to life imprisonment, an unlimited fine, or both.[103] In addition, oxycodone is a Schedule 2 drug per the Misuse of Drugs Regulations 2001 which “provide certain exemptions from the provisions of the Misuse of Drugs Act 1971.”[104]

United States

Under the Controlled Substances Act, oxycodone is a Schedule II controlled substance because it “has a high potential for abuse,” because it “has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions,” and because use of the drug “may lead to severe psychological or physical dependence.”[105] According to Section 829 of the Act, Schedule II drugs must be dispensed only with the written prescription of a practitioner except in certain situations (e.g., “dispensed directly by a practitioner, other than a pharmacist,” or “dispensed upon oral prescription (i.e. telephone)” in “emergency situations only“).[105] Furthermore, Section 829 specifies that prescriptions for Schedule II drugs cannot be refilled.[105]

As of April 2010 an “abuse resistant”, controlled release formulation of Oxycontin was approved for sale in the United States. The reformulated OxyContin is intended to lessen the ability to tamper with the opioid medication — from being cut, broken, chewed, crushed or dissolved, however, there is no evidence that the reformulation of OxyContin is less subject to misuse, abuse, diversion, overdose, or addiction.[106] The abuse resistant formulation is recognizable by a pill marking “OP” on one side and the milligrams of oxycodone contained within the pill on the other. The previous formulation has an “OC” marking replacing the “OP” of the new formulation.[107]